GSEA indicated that the P4HA1-high expression phenotype correlated with several cancer-related and immune-related signaling pathways, such as ubiquitin-mediated proteolysis, P53 signaling pathway, mismatch repair, nucleotide excision repair, cell cycle, DNA replication, TGF-β signaling pathway, PI3K/AKT/mTOR signaling pathway, IL1 mediated signaling pathway, regulation of macroautophagy, targets in activated B lymphocyte, and hypoxia. Here, P4HA1 is linked to cancer.