The KEGG path map shows that there are three pathways related to oxidative stress: (1) relaxin signaling pathway, (2) fluid shear stress and atherosclerosis pathway that activates downstream second messengers of PI3K-AKT, thus inducing eNOS expression, and (3) AGE-RAGE signaling pathway in diabetic complications, in which the receptor RAGE activates NADPH oxidase 2, thus leading to excessive ROS production. Here, RENBP is linked to atherosclerosis.