SIRT1 and brain ischemia: It has gained attention that Sirt1 has a neuroprotective effect against cerebral ischemia/reperfusion (I/R) injury (Chen et al., 2005 ▶; Rovillain et al., 2011 ▶; Cho et al., 2015 ▶; Zhang et al., 2016b ▶; Yan et al., 2019 ▶).