Pro-inflammatory cytokines such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6), are secreted by activated glial cells leading to increased post-stroke inflammation (Leonoudakis et al., 2017 ▶). The gene discussed is IL1B; the disease is Stroke.