Furthermore, IL-2 probably has a more important role when used in combination with 1619 BiKE, when compared with 161519 TriKE, because combined use of IL-2 with 1619 BiKE reduced the significant differences in the tumor growth and survival between the two treatment groups (1619 BiKE vs. 161519 TriKE). The gene discussed is IL2; the disease is neoplasm.