For instance, in ERα+/PR+/HER2− cells (MCF7 and ZR751) and ERα+/PR+/HER2+ cells (BT474) with intermediate CIN, the therapy (chemotherapy, hormonal therapy, or combined therapies) induced an increase in CIN greater than 70% and a higher CH, which correlated to cell survival. Here, ESR1 is linked to cervical squamous intraepithelial neoplasia.