ITGA4 and Miyoshi myopathy: In this study, CD49d and CD29 integrin overexpression in MM-MSC microvesicles correlated with patient staging and response to treatment; the concomitant inhibition of these molecules resulted in reduced uptake of MM-MSC microvesicles (but not normal donor MSC microvesicles), inhibition of MM cell signaling, expression of aggressiveness markers, and enhanced response to chemotherapy69.