Osteopontin, a hypoxia-driven phosphorylated glycoprotein, may promote stem cell-like properties and EMT in pancreatic cancer cells by activating the integrin αvβ3-Akt/Erk-forkhead box protein M1 (FOXM1) signaling in a paracrine manner85. The gene discussed is FOXM1; the disease is familial pancreatic carcinoma.