Moreover, exosomal miRNAs from hypoxic BM-MSCs promoted lung cancer cell metastasis via STAT3-induced EMT88 and hypoxia-conditioned MSCs promote HCC progression through yes-associated protein (YAP)-mediated lipogenesis reprogramming56, further suggesting that targeting the communication between MSC and cancer cells may be a potential target for anti-tumor therapy. Here, STAT3 is linked to cancer.