Interestingly and on the same hand, the CXCL8 supporting the survival and proliferation of acute myeloid leukemia (AML) cells via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway in the affected BM microenvironment would be mainly secreted by MSCs28. The gene discussed is CXCL8; the disease is acute myeloid leukemia.