In a coculture study with bladder cancer cells displaying stem cell-like properties (CD133+) and adipose-derived MSCs, the latter cells produced soluble mediators that: (i) increased the phosphorylation of molecules involved in cancer progression and drug resistance, such as p70 S6K, ERK1/2, and AKT1/2/3 in CD133+ cells from 5637 cell line; but also (ii) decreased the phosphorylation of those PI3K/Akt and MAPK signaling molecules in CD133+ cells from HB-CLS-1 cell line119. The gene discussed is PROM1; the disease is cancer.