Hypothyroidism development during trial (n=8) was more common among: patients with elevated anti-Tg titers at baseline (75% vs 24%, p=0.007), pre-cycle 3 (86% vs 27%, p=0.0044) and increase in titers between these two time points (71% vs 7%, p=0.00026); and in patients with an increase in anti-TPO titer between baseline and pre-cycle 3 (57% vs 7%, p=0.0029). This evidence concerns the gene TG and hypothyroidism.