The genes associated with IDD mainly include three types: (1) genes affecting intervertebral disc structure (ACAN, COL, etc.), (2) genes of metabolic enzymes affecting IVD metabolism (including matrix metalloproteinases [MMPs], cyclooxygenase- [COX-] 2, and tissue inhibitor of matrix metalloproteinases), and (3) inflammation-related genes (including interleukin- [IL-] 1 and IL-6). This evidence concerns the gene ACAN and intervertebral disk degenerative disorder.