The content of mucin in the mucosa was confirmed by histological evaluation with alcian blue staining which showed the restored mucosal epithelial layer, increased number and size of goblet cells and amount of acid glycoproteins (mainly sialomucins), and improved adherents and tight junctions leading to the appropriate cover of the mucus layer over the intestinal epithelium after CE and CE with SA treatment prior to colitis induction. This evidence concerns the gene MUC5AC and colitis.