NFE2L2 and hepatocellular carcinoma: Although NRF2 SUMOylation promoted KLK LUAD tumorigenesis and did not affect KLK LUAD cell apoptosis (Figure S2), as reported in HCC previously [23], the results in Figure 1 suggest that SUMOylation is critical for the inhibitory effect of NRF2 on KLK cell migration and invasion.