SOD1 and amyotrophic lateral sclerosis: Between these compounds, seven with best results were tested for aggregation and splitting of SOD1 induced by hydrogen peroxide in vitro at concentrations ranging from 20 μM to 100 μM. Compound 22 (Figure 2) revealed that quercetin-3-β-D-glucoside presented one of the best results, and for that, it may be a potential therapeutic inhibitor of misfolding and aggregation of SOD1 and, therefore, can delay clinical symptoms of ALS [57].