One of these studies was carried out by Kiaei and collaborators through the evaluation of the neurodegenerative activities of celastrol (41) (Figure 4), a triterpenoid, isolated from a Chinese plant Tripterygium wilfordii of the family Celastraceae. In this study, the neuroprotective effects were examined in the G93A SOD1 transgenic mice model for ALS. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.