In silico and in vivo tests of the cited studies demonstrated that extracts enriched with flavonoids, as well as their isolated, may act in the treatment of ALS by different mechanisms of action, such as decreased spinal cord injury, SOD1 inhibition, inhibition of motor neuron aggregation, inhibition caspase3, and decrease reactive oxygen species. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.