Although the expression of FGFR1 has been found in the nasal placode and in developing olfactory bulbs [6, 7], it is still unclear why some variants in FGFR1 affect the sense of smell (resulting in Kallmann syndrome (KS)) [8] while others do not (leading to normosmic isolated hypogonadotropic hypogonadism (nIHH) [9]. This evidence concerns the gene FGFR1 and hypogonadotropic hypogonadism.