STAT3 and central nervous system cancer: We found that STAT3/p-STAT3 overexpression in glioma patients was associated with worse overall survival (hazard  ratio  (HR) = 1.40, 95%confidence  interval  (CI) = 1.05 ~ 1.86, P = 0.020), progression-free survival (HR = 2.05, 95%CI = 1.63 ~ 2.58, P < 0.001), and better recurrence-free survival (HR = 0.37, 95%CI = 0.15 ~ 0.95, P < 0.039).