Regarding miRNA pairs coregulating a large number of target genes, suppression of miR-30a-3p and miR-30c-2-3p promotes expression of hypoxia-inducible factor-2α (HIF-2α), which weakens HIF-1α-mediated ccRCC inhibition [47]. The gene discussed is HIF1A; the disease is nonpapillary renal cell carcinoma.