SOD1 and Anxiety: Other results on the ability of oxytocin to improve memory, anxiety, and oxidative stress biomarkers in a methionine-induced rat model of schizophrenia [19] showed an increase in the specific activity of GPx and in levels of MDA in the temporal lobe of rat models, but with no significant modifications in SOD specific activity, which was explained by the fact that SOD represents the first enzyme in contact with free radicals and its increase could be attributed to some compensatory actions [4].