Regarding biological processes, Shan-Zhu-Yu might affect the activity of G protein-coupled amine receptors, neurotransmitter receptors, steroid hormone receptors, nuclear receptors, G protein-coupled neurotransmitter receptors, protein heterodimerization, an acetylcholine receptor, and phosphatidylinositol phospholipase C in the treatment of depression by acting on hormone, catecholamine, and adrenergic receptors as well as nuclear receptor binding (Table 2 and Figure 3(a)). The gene discussed is PLCG1; the disease is major depressive disorder.