Potential risk factors for OS by the univariable Cox analysis including age (P=0.026), HGB (P=0.001), serum Ca (P=0.019), Ccr (P < 0.001), symptom (P=0.001), surgery (P=0.001), tumour size (P < 0.001), tumour type (P < 0.001), TNM stage (P < 0.001), Fuhrman grade (P < 0.001), RLR (P < 0.001), and AFR (P < 0.001) were enrolled into the multivariable Cox analysis (Table 3). The gene discussed is CYGB; the disease is neoplasm.