MRC1 and neoplasm: Since it is known that MM BM is infiltrated by tumor-associated CD163+macrophages leading to an unfavorable prognosis [50], Kvorning et al. demonstrated that total concentration of soluble macrophagic antigens, CD163 and CD206, did not vary among 32 newly diagnosed MM patients, 8 MGUS patients and healthy donors; on the contrary, they observed a significantly higher concentration of both CD163+ and CD206+EVs in plasma of MM patients at diagnosis as compared to remission patients, MGUS and healthy donors.