BCL2 and esophageal squamous cell carcinoma: The ratio of Bax/Bcl-2 is a reliable marker for apoptosis detection.31 The results indicated a reduction in the ratio of Bax/Bcl-2 further confirming that F. nucleatum inhibits apoptosis in ESCC cells upon 5-FU, CDDP, and Docetaxel exposure (Fig. 4c).