For example, in oesophageal squamous cell carcinoma, miR-150 induces MET-like changes by inducing degradation of Zeb-1 mRNA, inhibiting tumorigenicity and tumour growth in a mouse xenograft model.25 Research on the EMT and MET has also uncovered numerous novel signalling pathways, including TGF-β, Wnt, Notch, Hedgehog and PI3K pathways, that facilitate EMT in tumour cells.16,22. This evidence concerns the gene ZEB1 and neoplasm.