VIM and urinary bladder carcinoma: For example, VIM is highly expressed in metastatic tumours including bladder cancers with high tumour grade and stages.57 Linking to CRISPR/Cas9-based VIM knockout data revealed that vimentin dependency across cell lines with metastatic properties is higher than in cell lines without metastatic properties (p = 4.92 × 10−2, Fig. 3e).