Although the mechanism underlying these results is unknown, it has been discussed that retinal ischemia at the detached areas in eyes with macula-on RRD reduces the macular blood flow via the upregulation of endothelin-1, leading to reduced ERG responses16,17, Eshita et al.18 measured the macular blood flow in 28 patients with macula-n RRD using scanning laser doppler flowmetry and found that the mean blood flow ratio in the affected eye was lower than that in the fellow eye both before and after the surgery. Here, EDN1 is linked to retinal ischemia.