The resulting heatmap showed that in the majority of malignancies, TILs were significantly correlated with multiple representative ICD mediators, such as CALR (Fig. 9a), LRP1 (Fig. 9b), ANXA1 (Fig. 9c), FPR1 (Fig. 9d), TLR3 (Fig. 9e), IFNAR1 (Fig. 9f), PANX1 (Fig. 9g), and P2RX7 (Fig. 9h). The gene discussed is ANXA1; the disease is cancer.