In a broad genomic characterization of thyroid cancers in The Cancer Genome Atlas (TCGA),  Cancer Genome Atlas Research Network developed BRAF-RAS score (BRS), a 71-gene expression signature designed to quantify the extent to which the gene expression profile of a given tumor resembles either the BRAFV600E or RAS-mutant profiles [1]. The gene discussed is BRAF; the disease is neoplasm.