In some circumstances (e.g., dermatitis, asthma, and graft-versus-host disease), MCs possess immunosuppressive properties mediated by the production of immunoregulatory cytokines such as IL-2, IL-10, IL-33, and TGF-β.19,20 Considering these previous results together with our current ones (Fig. 6), it is plausible to suggest that desensitized MCs behave as a form of regulatory cells producing these regulatory cytokines and categorized as regulatory MCs, and that they directly or indirectly (via the induction of Treg cells) suppress undesired allergic responses. Here, IL33 is linked to skin disorder.