IL2 and food allergy: We found here that, along with IL-2 expression, IL-10 expression was upregulated in OIT-treated MCs (Fig. 6g); thus, IL-2 and IL-10 dual synthesis in response to OIT-induced mucosal desensitization of MCs resulted in a duplex suppressive pathway of induction of Treg cells and direct inhibition of Th2 pathway for the efficient induction of oral unresponsiveness against food allergy.