Among the most enriched Lrp6 interactors we found TFG, a protein that was first identified in papillary thyroid carcinomas as a result of an in-frame oncogenic rearrangement between its N-terminal region and the tyrosine kinase domain of Neurotrophic tyrosine kinase receptor type 1 (NTRK1, also designated as Trk)39. The gene discussed is LRP6; the disease is differentiated thyroid carcinoma.