Since the SNPs at 11q23.3 region harbouring apolipoprotein coding genes namely APOA1, APOC3, APOA4, APOA5 and regulatory genes BUD13, ZPR1, SIK3 were found to be associated with defective lipid metabolism, this region was thought to play an important role in atherosclerosis and CAD risk. The gene discussed is SIK3; the disease is atherosclerosis.