Further the interaction analysis between rs7865618 of 9p21.3 and SNPs rs2187126, rs1263163, rs2849165 of 11q23.3 indicated that the intronic variant (rs2187126) of BUD13 gene and intergenic variants (rs1263163, rs2849165) of APOA4-APOA5 genes have a profound risk towards CAD. The gene discussed is APOA4; the disease is coronary artery disorder.