In those who were out of target, there was a significant difference between the PKG+ and PKG− arm for MDS-UPDRS Total (7.3, 95% CI 3.4–11.2, P = 0.002) and III (5.3, 95% CI 2.4–8.3, P = 0.0004), but not for PDQ39 and SENS PD (although these approached significance in people who were bradykinetic at onset: P = 0.07 and P = 0.05 respectively). The gene discussed is PRKG1; the disease is Parkinson disease.