Previous work has also shown that the sequestration of dopamine is impaired downstream of Parkinson’s disease-associated environmental factors, and many studies have identified dysregulation of dopamine sequestration and release downstream of other Parkinson’s-associated genetic factors including misfolded α-synuclein, VPS35 variants, and LRRK2 variants43–49. This evidence concerns the gene LRRK2 and Parkinsonism.