Furthermore, GSEA of tumor RNA-seq identifies genes with HIF1A transcription factor binding sites as enriched within brain tumors versus mammary tumors, using two different genesets for HIF1A target genes from the Molecular Signatures Database Transcription Factor Targets database (HIF1_Q3: P = 0.002; HIF1_Q5: P = 0.038) (Supplementary Fig. 7 and Supplementary Data 3). Here, HIF1A is linked to breast cancer.