Gene set enrichment analysis (GSEA) for pathways enriched within the Molecular Signatures Database hallmarks of cancer genesets29 identifies three genesets enriched in both Brx-50 F1 and Brx-82 F1 lines: Hypoxia, KRAS Signaling Up, and TNFα Signaling via NF-κB (FDR < 0.25). This evidence concerns the gene TNF and cancer.