CD4 and neoplasm: Consistent with the reduction in tumor size, the tumors that did not shrink in response to anti-PD-1, Neo-Lpx, or the combination therapy had a significantly higher number of CD8+ TILs compared to CD4+ TILs (Fig. 7f), showing that the monotherapy induction of CD8+ TILs is not sufficient for complete tumor clearance or reduction.