TGFB1 and neoplasm: Strikingly, loss of myofibroblasts upon TGFβ-blockade was contrasted by the appearance of a transcriptionally unique population of CAFs (thereafter referred to as interferon-licensed CAFs, ilCAFs, Fig. 4b, c in purple), revealing a broader plasticity of the mesenchymal stromal compartment of the tumor microenvironment.