The major difference between Keap1-KO and NQO1-Tg mice in terms of the molecular mechanisms of regulating intermediary metabolism stems is that deletion of Keap-1 potentially affects the expression of >200 genes downstream of Nrf2 with conflicting outcomes in terms of glucose or lipid homeostasis2,55,56, whereas selective overexpression of NQO1 protects mice from diet-induced insulin resistance. This evidence concerns the gene KEAP1 and Insulin resistance.