To determine whether TRIB3 was required for not only lymphoma initiation but also the malignancy of established lymphomas, we crossed Trib3F/F mice with CreERT2 mice to generate CreERT2Trib3F/F mice (Supplementary Fig. 1j), enabling temporally controlled Cre activation by tamoxifen treatment. The gene discussed is TRIB3; the disease is lymphoma.