Knocking out TRIB3 in primary human DLBCL (T69), BL (T4 and T5), and PTCL (T144) cells freshly isolated from patient tumors or lymphoma cell lines (Fig. 2e and Supplementary Table 1) reduced the colony-formation units (CFUs) and proliferation (Fig. 2f, g). The gene discussed is TRIB3; the disease is lymphoma.