Mø_c5-Mø_c7 showed a strong donor phenotype and were defined as monocytic myeloid-derived suppressor cells (M-MDSCs, 8.78%, 8.16%, and 7.95%, respectively), characterized by the high expression of S100A12, S100A9, and S100A818 (Supplementary Fig. S2g), as well as CCR2, which could facilitate their trafficking to tumor site19. Here, S100A12 is linked to neoplasm.