IGHD and neoplasm: We also recovered five subsets of B cells (3240 cells, Supplementary Fig. S9a–g), including memory B cells (B_c1, marker gene: AIM2 and GPR183, 48.02%), unswitched naïve B cells (B_c2, marker genes: TCL1A, IGHD, and IL4R, 24.38%), plasma cells (B_c3, marker genes: XBP1, MZB1, and CD38, 13.86%), tumor-specific B cells (B_c4, marker genes: APOA2, APOC1, and APOA1, 8.58%), and atypical memory B cells (B_c5, marker genes: SLC11A1, FGR, and TNFRSF1B, 5.15%).