Results showed that interactions participating in immune activation and anti-tumor response, such as, CXCL9-CXCR3, CXCL9-DPP4, XCL2-XCR1, and TNFSF4-TNFRSF4 upregulated in tumors, partly due to the continuous stimulation of tumor antigens. Here, XCL2 is linked to neoplasm.