In one study, fluid shear increased apoptosis in several tumor cell types, while no negative effects of shear were found in non-tumor cells.21 In another study, daily application of LIV increased apoptosis of MDA-MB-231 cells.47 We did not observe increased cell death directly following LIV; however, LIV increased expression of the membrane death receptor FAS, resulting in increased Fas ligand-mediated apoptosis following LIV. Here, FAS is linked to neoplasm.