Some articles have suggested that lower levels of IgA in the saliva of children with thalassemia may be the cause of more caries in them compared to healthy children.27,37 In some other studies, endocrine dysfunction in patients with thalassemia is considered to be the main cause of a higher chance of tooth decay in these patients.26 Given the spread of thalassemia in Iran, and especially in the northern regions of the country, it seems necessary to establish centers for screening dental caries among these patients.38 This evidence concerns the gene CD79A and dental caries.