Third, the epigenetic status of the CRNDE locus in APL cells showed a high level of active histone marks (GSE1888620) (Fig. 2c), such as H3K4 trimethylation and H3K9K14 acetylation, and an enriched binding of histone acetyltransferase P300, along with the loss of repressive marks, such as H3K9me3. The gene discussed is EP300; the disease is acute promyelocytic leukemia.