First, CRNDE expression was remarkedly higher in APL samples, as compared with non-APL AML (GSE1315918,19), as well as normal counterparts, including normal promyelocytes, CD34+ hematopoietic stem cells and polymorphonuclear neutrophils (GSE126629) (Fig. 2a). The gene discussed is CRNDE; the disease is acute promyelocytic leukemia.