SAMHD1 and HIV-1 infection: We next infected MDMGs and donor-matched MDMs with HIV-1 in the absence or presence of the simian immunodeficiency virus of macaques (SIVmac) Vpx containing virus-like particles (VLPs), which degrades SAMHD1 (27, 28) and enhances HIV-1 infection of myeloid cells (29).