TREX1 and infectious disease: Our earlier findings concerning the bioactivities of CRV and CA, now confirmed to be AgamORco antagonists, which were shown to repel effectively An. gambiae and Culex spp mosquitoes (33), raised the question of whether these as well as the new antagonists identified in this study were also active against Aedes, the third major mosquito genus of the Culicidae family, which comprises multiple hematopagous species and infectious disease vectors.