TRIM25 and infection: In the past, it has been confirmed that TRIM25 is expressed in almost all chicken tissues and organs and is expressed at relatively high levels in immune organs, such as the spleen, thymus, and bursa; moreover, TRIM25 can be clearly upregulated 2 days after infection with Newcastle disease virus (NDV) [14, 15], suggesting that TRIM25 might participate in some antiviral responses in these organs as an important component.