These selected genes were ICOS (affected by DNA methylation in blood during acute infection, DEG), FOXP1 (LN and blood chronic infection, DEG), LTA (LN and blood chronic infection), MAPK12 (blood acute and chronic infection), MAPK-associated protein 1 (MAPKAP1, blood chronic infection), nitrogen permease regulator 2-like protein (NPRL2) and RUNX3 (LN acute and chronic), PRKCZ (LN acute and chronic, DEG), NFKB1 and sphingomyelin synthase 2 (SGMS2, LN chronic infection). Here, ICOS is linked to lobular neoplasia.