TWIST-1 expression and function have been correlated with the epigenetic regulator Enhance of Zeste Homolog 2 (EZH2) in mediating SCS cranial bone cell growth and differentiation [32], where Ezh2 knockdown in the mesenchymal lineage leads to craniosynostosis and other skeletal deformities [34]. The gene discussed is TWIST1; the disease is craniosynostosis.