Examination of cases classified into luminal A (N = 1933) and luminal B (N = 1149) subtypes identified that elevated CTSV expression was associated with poor prognosis in both subtypes, with the significance much greater in luminal A tumours (HR = 1.582, log-rank p = < 0.0001) compared to luminal B tumours (HR = 1.237, log-rank p = 0.0335) (Fig. 1d, e). Here, CTSV is linked to neoplasm.