Moreover, combination therapy for HL60/ADR cells, K562/A02 cells, THP-1/ADR and primary AML cells decreased HDAC3, P-AKT, CDK2 protein expression, but increased P21 protein expression in a dose-dependent manner (Fig. 5g, i; Figure S5F; Figure S5H). Here, HDAC3 is linked to acute myeloid leukemia.