ACE and hydrops fetalis: In our present study, we focus on the effects of prophylactic, individually applied drug treatments using the same HF medications as in our previous model [β-blocker (bisoprolol; BB), angiotensin-converting enzyme inhibitor (perindopril; ACEI), and aldosterone antagonist (eplerenone; AA)] in order to clarify their distinct roles in the prevention of DOX cardiotoxicity.