Lei and co-workers [83] reported that a combination therapy of avasimibe (a small molecule inhibitor of acyl-coenzyme A-cholesterol acytransferase-1 that can strengthen CD8+ T cell activity) and a nano-drug delivery system containing doxorubicin generates a better efficacy in tumor growth inhibition compared with monotherapy in 4T1 tumor‐bearing mice. The gene discussed is CD8A; the disease is neoplasm.