Additionally, incorporation of the immunomodulator polysaccharides isolated from natural herb into nanocomposites was found to activate DCs and enhance cytokine production and proliferation of CD4+ and CD8+ T cells, and a combination of these nanoparticles with chemotherapeutic doxorubicin significantly inhibits 4T1 tumor growth and lung metastasis without evident toxicity [65]. The gene discussed is CD8A; the disease is neoplasm.