CD8A and liver cancer: A recent study demonstrated that nanoparticles loaded with IL-12 and modified with CD8 and glypican-3 antibodies on the surface are able to interact specifically with CD8+ T cells and HepG-2 liver cancer cells, respectively, via the antibody-antigen interactions, leading to the formation of T cell-HepG-2 cell clusters and efficient delivery of IL-12 to CD8+ T cells for T cell activation [46].