CD8A and neoplasm: The study found that glutamine is the major metabolic source for dysfunctional CD8+PD-1+TIM-3+ T cells in immune checkpoint inhibitors resistant melanoma [119].Glucose is another major contributor to cancer metabolism, as it is a nutrient that is required for the proliferation of both T cells and tumor cells and the increased consumption of glucose by tumors leads to a decrease in the amount of glucose levels within the TME and immune cells, creating competition for glucose between T cells and tumor cells for survival and proliferation.