Previous pharmacological mechanistic investigations of stemazole based on a network pharmacology approach identified caspase-3, caspase-8, AKT1, MAPK8, MAPK14 as the possible direct targets of stemazole and as being enriched in MAPK signalling, which is highly relevant to the occurrence and progression of neurodegenerative diseases [16]. Here, MAPK8 is linked to neurodegenerative disease.