STAT3 and plasma cell myeloma: Several researchers pointed out to a correlation between berberine treatment and expression of non-coding RNAs, either lncRNAs or microRNAs [47]. It was shown that berberine suppresses interleukin 6 (IL-6), a factor required for cell growth in multiple myeloma cells (U266), through negative regulation of the STAT3, and this induces inhibition of miR-21 expression [48].