Of patients in the milder AP (n = 94) and severe AP (n = 46) group, those in the latter group with a Cr/Alb value ≥ 3.43 had a more intense heart rate and respiratory rate (P < 0.05), impaired laboratory data, including those pertaining to blood urea nitrogen, Cr, Alb, white blood cells, platelets and the APACHE II score (P < 0.05), higher morbidity values associated with post-operative complications, including electrolyte disorders, respiratory failure, hemorrhage, shock and renal failure (P < 0.05), and higher rates of re-operation and mortality (P < 0.001). The gene discussed is ALB; the disease is Renal insufficiency.